The Cysteine Protease Cathepsin B Is a Key Drug Target and Cysteine Protease Inhibitors Are Potential Therapeutics for Traumatic Brain Injury
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چکیده
منابع مشابه
Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.
Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion, arthritis, osteoporosis, and microbial infections. Targeting this enzyme family is therefore one strategy in the development of new chemotherapy for a number of diseases. Little is known, however, about the efficacy, selectivity, and safety of cysteine protease inhibitors in cell culture or in vivo. We now ...
متن کاملIsothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF.
Isothiazolones and 5-chloroisothiazolones react chemoselectively with thiols by cleavage of the weak nitrogen-sulfur bond to form disulfides. They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern. Furthermore, enzyme kinetics and mass spectroscopy indicate ...
متن کاملCysteine Protease Inhibitors and Parasitic Diseases
ABBREVIATIONS BBB: Blood brain barrier, CP: Cysteine protease, CPI: cysteine protease inhibitor, E-64: Epoxid compound: Clonazepam©, E/S: Excretory-secretory, FP2: Falcipain-2HDAC: Histone deacetylases, IFN: Interferon, LC: Lactacystin, NO: Nitrous oxide, PCD: Programmed cell death, PMN: Polymorphonuclear neutrophil granulocytes, PMSF: Phenyl-methylsulfonyl fluoride, PVS: Polyvenyl sulfone, SBT...
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Taking into account a previous report of an unidentified enzyme from macrophages acting as a kininase, the ability of cysteine proteases to degrade kinins has been investigated. Wild-type fibroblast lysates from mice, by contrast with cathepsin K-deficient lysates, hydrolysed BK (bradykinin), and released two metabolites, BK-(1-4) and BK-(5-9). Cathepsin K, but not cathepsins B, H, L and S, cle...
متن کاملDeficiency of the cysteine protease cathepsin S impairs microvessel growth.
During angiogenesis, microvascular endothelial cells (ECs) secrete proteinases that permit penetration of the vascular basement membrane as well as the interstitial extracellular matrix. This study tested the hypothesis that cathepsin S (Cat S) contributes to angiogenesis. Treatment of cultured ECs with inflammatory cytokines or angiogenic factors stimulated the expression of Cat S, whereas inh...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2014
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2013.2944